Publications

1 March 2022

Antiallodynic action of phosphodiesterase inhibitors in a mouse model of peripheral nerve injury

Neuropathic pain arises as a consequence of a lesion or disease affecting the somatosensory nervous system. It is accompanied by neuronal and non-neuronal alterations, including alterations in intracellular second messenger pathways. Cellular levels of 3′,5′-cyclic adenosine monophosphate (cAMP) and…

28 February 2022

High-Throughput Screening for Extracellular Inhibitors of the FLT3 Receptor Tyrosine Kinase Reveals Chemically Diverse and Druggable Negative Allosteric Modulators

Inhibiting receptor tyrosine kinases is commonly achieved by two main strategies targeting either the intracellular kinase domain by low molecular weight compounds or the extracellular ligand-binding domain by monoclonal antibodies. Identifying small molecules able to inhibit RTKs at the…

1 February 2022

Investigating cold Aδ fibers in the 0-40 °C temperature range: A quantitative sensory testing and evoked potentials study

Objective: To evaluate the activity of cold Aδ-type fibers to thermal stimuli above human skin temperature (i.e., >32 °C). Authors: Ségolène Lithfous, Louise Trocmet, Thierry Pebayle, Olivier Després, André Dufour See the publication

1 December 2021

Action of mefloquine/amitriptyline THN101 combination on neuropathic mechanical hypersensitivity in mice

Tricyclic antidepressants that inhibit serotonin and noradrenaline reuptake, such as amitriptyline, are among the first-line treatments for neuropathic pain, which is caused by a lesion or disease affecting the somatosensory nervous system. These treatments are, however, partially efficient to…

8 November 2021

Behavioral characterization, potential clinical relevance and mechanisms of latent pain sensitization

Chronic pain is a debilitating disorder that can occur as painful episodes that alternates with bouts of remission and occurs despite healing of the primary insult. Those episodes are often triggered by stressful events. In the last decades, a similar situation has been evidenced in a wide variety…

1 October 2021

Spatial Acuity of the Nociceptive System and Spatial Summation of Pain: Potential Implications for the Clinic

Previous studies investigating spatial acuity measured by two-point discrimination threshold concluded that the nociceptive system is less accurate than the innocuous tactile system. In the discussed article, the authors point out that the nociceptive system is more accurate than the tactile system…

1 September 2021

Binge sucrose-induced neuroadaptations: A focus on the endocannabinoid system

Binge eating, the defining feature of binge eating disorder (BED), is associated with a number of adverse health outcomes as well as a reduced quality of life. Animals, like humans, selectively binge on highly palatable food suggesting that the behaviour is driven by hedonic, rather than metabolic,…

1 July 2021

Sphingosine-1-phosphate Receptor Subtype 1 Antagonists may be the Unmet Medical Need for Morphine-induced Hyperalgesia and Antinociceptive Tolerance

Opioids such as morphine are frequently used for chronic pain management despite their many adverse effects. Ongoing research aims at either finding new treatments to replace opioids or reducing its heavy adverse effects due to long-term use: opioid-induced hyperalgesia and antinociceptive…

1 July 2021

Midbrain and Lateral Nucleus Accumbens Dopamine Depletion Affects Free-choice High-fat high-sugar Diet Preference in Male Rats

Dopamine influences food intake behavior. Reciprocally, food intake, especially of palatable dietary items, can modulate dopamine-related brain circuitries. Among these reciprocal impacts, it has been observed that an increased intake of dietary fat results in blunted dopamine signaling and, to…

1 June 2021

P2X7 Receptors and TMEM16 Channels Are Functionally Coupled with Implications for Macropore Formation and Current Facilitation

P2X7 receptors (P2X7) are cationic channels involved in many diseases. Following their activation by extracellular ATP, distinct signaling pathways are triggered, which lead to various physiological responses such as the secretion of pro-inflammatory cytokines or the modulation of cell death. P2X7…

Antiallodynic action of phosphodiesterase inhibitors in a mouse model of peripheral nerve injury

High-Throughput Screening for Extracellular Inhibitors of the FLT3 Receptor Tyrosine Kinase Reveals Chemically Diverse and Druggable Negative Allosteric Modulators

Investigating cold Aδ fibers in the 0-40 °C temperature range: A quantitative sensory testing and evoked potentials study

Action of mefloquine/amitriptyline THN101 combination on neuropathic mechanical hypersensitivity in mice

Behavioral characterization, potential clinical relevance and mechanisms of latent pain sensitization

Spatial Acuity of the Nociceptive System and Spatial Summation of Pain: Potential Implications for the Clinic

Binge sucrose-induced neuroadaptations: A focus on the endocannabinoid system

Sphingosine-1-phosphate Receptor Subtype 1 Antagonists may be the Unmet Medical Need for Morphine-induced Hyperalgesia and Antinociceptive Tolerance

Midbrain and Lateral Nucleus Accumbens Dopamine Depletion Affects Free-choice High-fat high-sugar Diet Preference in Male Rats

P2X7 Receptors and TMEM16 Channels Are Functionally Coupled with Implications for Macropore Formation and Current Facilitation

Appel à Participants au projet de recherche "Emile"

PhD-Students Marion Gaborit and Volodya Hovhannisyan attended the International Narcotic research conference in Valencia (2022)

PhD-Student Sarah Journée attended the "School of Neuroscience: from cellular mechanisms to disease modeling"

PhD-Student Marion Schott attended the 2022 Congress of the European Pain Federation (EFIC) in Dublin

APPEL À VOLONTAIRES VIVANT AVEC UNE DOULEUR CHRONIQUE

Traboule Labs - a new EURIDOL partnership!

Matilde Cordero-Erausquin and Meggane Melchior are laureates of the 2022 IDEX Attractivity Grant

Conference Anthropological aspects of Pain

Conférence : L'ocytocine au cœur de nos émotions

Prof. Pierre Kuhn is Neonatologist of the Year 2021