Publications

7 March 2023

Optical control of PIEZO1 channels

"PIEZO proteins are unusually large, mechanically-activated trimeric ion channels. The central pore features structural similarities with the pore of other trimeric ion channels, including purinergic P2X receptors, for which optical control of channel gating has been previously achieved with…

Top News

24 February 2023

An analgesic pathway from parvocellular oxytocin neurons to the periaqueductal gray in rats

"The hypothalamic neuropeptide oxytocin (OT) exerts prominent analgesic effects via central and peripheral action. However, the precise analgesic pathways recruited by OT are largely elusive. Here we discovered a subset of OT neurons whose projections preferentially terminate on OT receptor…

7 September 2023

Effect of a web-based app music intervention in the management of chronic pain: a randomised controlled trial by type of pain

Pierrick Poisbeau from the Euridol consortium participated in this interdisciplinary study. Click on the image to see the details!

14 October 2022

Identification of bacterial lipopeptides as key players in irritable bowel syndrome (IBS)

"Objectives Clinical studies revealed that early-life adverse events contribute to the development of IBS in adulthood. The aim of our study was to investigate the relationship between prenatal stress (PS), gut microbiota and visceral hypersensitivity with a focus on bacterial lipopeptides…

4 July 2022

Modulation of GABAergic Synaptic Transmission by NMDA Receptors in the Dorsal Horn of the Spinal Cord

"The dorsal horn (DH) of the spinal cord is an important structure involved in the integration of nociceptive messages. Plastic changes in the properties of neuronal networks in the DH underlie the development of analgesia as well as of hyperalgesia and allodynia in acute and chronic pain states.…

13 June 2022

The Human SCN9AR185H Point Mutation Induces Pain Hypersensitivity and Spontaneous Pain in Mice

"The voltage-gated sodium channel Nav1.7 is encoded by SCN9A gene and plays a critical role in pain sensitivity. Several SCN9A gain-of-function (GOF) mutations have been found in patients with small fiber neuropathy (SFN) having chronic pain, including the R185H mutation. However, for most of these…

1 June 2022

Evidence of Sexual Dimorphism in Pain: A Dialogue Between Macrophages and Sensory Neurons via the IL-23/IL-17A/TRPV1 Axis Is a Prevalent Generator of Mechanical Allodynia in Females

"Chronic pain is a very disabling disease, which statistically affects women more than men. More and more studies are looking at this sexual difference. In particular, the study by Luo et al., published on September 1, 2021, highlights a particular neuroimmune axis that induces mechanical pain…

12 May 2022

Morphine-3-Glucuronide, Physiology and Behavior

"Morphine remains the gold standard painkiller available to date to relieve severe pain. Morphine metabolism leads to the production of two predominant metabolites, morphine-3-glucuronide (M3G) and morphine-6-glucuronide (M6G). This metabolism involves uridine 5′-diphospho-glucuronosyltransferases…

5 May 2022

Impact of COVID-19 on chronic pain structures: data from French national survey

"Aims: The authors evaluated the impact of the first COVID-19 pandemic wave on French chronic pain structures (CPS). Methods: An online survey assessed CPS resource allocation, workflow and perceived impact on patient care. Results: All CPS workflow was severely impacted by the reallocation of 42%…

1 May 2022

Behavioral characterization, potential clinical relevance and mechanisms of latent pain sensitization

"Chronic pain is a debilitating disorder that can occur as painful episodes that alternates with bouts of remission and occurs despite healing of the primary insult. Those episodes are often triggered by stressful events. In the last decades, a similar situation has been evidenced in a wide variety…

Optical control of PIEZO1 channels

An analgesic pathway from parvocellular oxytocin neurons to the periaqueductal gray in rats

Effect of a web-based app music intervention in the management of chronic pain: a randomised controlled trial by type of pain

Identification of bacterial lipopeptides as key players in irritable bowel syndrome (IBS)

Modulation of GABAergic Synaptic Transmission by NMDA Receptors in the Dorsal Horn of the Spinal Cord

The Human SCN9AR185H Point Mutation Induces Pain Hypersensitivity and Spontaneous Pain in Mice

Evidence of Sexual Dimorphism in Pain: A Dialogue Between Macrophages and Sensory Neurons via the IL-23/IL-17A/TRPV1 Axis Is a Prevalent Generator of Mechanical Allodynia in Females

Morphine-3-Glucuronide, Physiology and Behavior

Impact of COVID-19 on chronic pain structures: data from French national survey

Behavioral characterization, potential clinical relevance and mechanisms of latent pain sensitization

We're HIRING! Join the EURIDOL Team!

Parution de l'ouvrage collectif "Penser le soin pour une médecine humaine et sociale", sous la direction de Philippe Cornet - Préface de Gérard Ostermann.

Science and video games : Euridol PhD-Student Guillaume Reho talks about his participation in the first Scientific Game Jam in Strasbourg

Optical control of PIEZO1 channels

PhD-Student Volodya Hovhannisyan tells us how he organised a symposium on "Sex differences in pain experience and management", which turned out to be larger than expected!

An analgesic pathway from parvocellular oxytocin neurons to the periaqueductal gray in rats

PhD-Students Robin Kuster and Lucien Ruelle Le Glaunec write about the Pain Summer School in Heidelberg, Oct. 2022

Effect of a web-based app music intervention in the management of chronic pain: a randomised controlled trial by type of pain

PhD-Student Gaëlle Awad attended the "International Drug Association Research Programme" in Nice

Appel à Participants au projet de recherche "Emile"