Biotechnology and Cellular Signaling (BSC) | UMR7242 Director: Guy Zuber
Team "GPCRs in Pain & Inflammation"
Frédéric Simonin
After an initial training as a molecular biologist, Frédéric Simonin, currently a research director at the CNRS, became interested in opioids and their receptors. Presently, his team studies three main topics: the role of RF-amide peptide receptors in opiate-induced hyperalgesia and persistent pain, the role of different chemokines in the neuroinflammatory processes associated with hyperalgesia and the role of intracellular partners of GPCRs, which are the GPRASP proteins and particularly the first member of the family GPRASP-1, in adaptations linked to the repeated stimulation of different GPCRs, including opioid receptors.