Laboratory of Cognitive and Adaptive Neuroscience (LNCA) | UMR7364 Director: Jean-Christophe Cassel
Pierrick Poisbeau is Professor of Neuroscience. His team of basic researchers and clinicians work on the interplay between adverse life events and chronic pain. Research is mainly conducted in humans, focusing on vulnerable populations such as premature infants, women who have experienced violence or homelessness, and adults suffering from chronic pain. This work is complemented by mechanistic analysis using preclinical models of prematurity, adverse life events or chronic pain. Clinical research is carried out at the Hautepierre-Strasbourg Hospital, at the Neonatal Intensive Care Unit and at the Centre for the Study and Treatment of Pain (CETD). The methods of analysis range from the most integrated (behaviour, imaging, electrophysiology) to the most molecular (transcriptomics, methylome, neurochemistry). The interventional studies carried out are mainly in the field of non-pharmaceutical interventions such as hypnosis, music therapy, adapted physical activity or virtual reality.
André Dufour is a professor of cognitive neuroscience and statistics. He studies changes in the perception of pain during aging. These research projects focus in particular on the alteration of nociceptive fibers in the elderly. For this, he uses sensory quantification techniques and electrophysiological measurements.
Katia Befort is a CNRS research fellow, her team is interested in the behavioural and molecular adaptations, including epigenetics, that occur in addictive behaviours. The team studies the long-term effects of psychostimulants (cocaine), analgesic drugs (opioids and cannabinoids), or natural rewards (sugar, fat) in brain reward related circuits. Compulsive consumptions (intake of alcohol, sugary and fatty food) are particularly impaired in patients suffering from chronic pain. The team therefore seeks to deepen its knowledge on the mechanisms involved in addictive behaviours in pain conditions.