The “Opioid System, Nociception & Pain” team, led by Dominique Massotte, begins 2026 with three major publications in the field of pain neuroscience:
“Divergence in Mu and Delta Opioid Receptor Pharmacology in Neurons and Antinociceptive Efficacy in Neuropathic Pain: Insights from MP135 and CYM51010.”
Brit J Pharmacol (in press) DOI:10.1111/bph.70285 (2026)
→ Inquimbert P., Fitterer C., Hugel S., Jesic M., Goumon Y., Andry V., Schneider S., Daubeuf F., Faouzi A., Doridot S., Majumdar S., Bihel F., Schmitt M.,Massotte D.
“GPRASP1 deletion suppresses antinociceptive tolerance during chronic activation of delta opioid receptor in persistent pain.”
Biomedicine & Pharmacotherapy 194, 11913. DOI: 10.1016/j.biopha.2025.118913
→ Kaeffer J., Straub M.-L., Le Coz G.-M., Quillet R., Kugler V., Petit-Demoulière N., Gerum M., Zeder-Lutz G., Doridot S., Dumas M., Chicher J., Hammann P., Marin P., Vandermoere F., Massotte D., Simonin F. and Lecat S. (2026)
“Chronic constriction of the sciatic nerve does not induce mood-related comorbidities in female mice.”
Brain Behavior & immunity 134, 106086. (2026)
→ Gaborit M., Leboulleux Q., Willem N., Sagot C., Doridot S., Herbeaux K., Kremer M., Bery A., Befort K. and Massotte D.
